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Hereditary diffuse gastric cancer: What the clinician should know

1 Jan 2015

Abstract excerpt

Hereditary diffuse gastric cancer (HDGC) is an inherited autosomal dominant syndrome with a penetrance of up to 80% affecting diverse geographic populations. While it has been shown to be caused mainly by germline alterations in the E-cadherin gene (CDH1), problematically, the genetic diagnosis remains unknown in up to 60% of patients. Given the important knowledge gaps regarding the syndrome, asymptomatic...

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PMID: 26380059
DOI: 10.4251/wjgo.v7.i9.153

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