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Article

Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: a prospective cohort study.

The Lancet. Oncology - 1 Apr 2023

Asif Bilal, Sarvestani Amber Leila, Gamble Lauren A, Samaranayake Sarah G, Famiglietti Amber L, Fasaye Grace-Ann, Quezado Martha, Miettinen Markku, Korman Louis, Koh Christopher, Heller Theo, Davis Jeremy L

Abstract excerpt

BACKGROUND: Loss of function variants in CDH1 are the most frequent cause of hereditary diffuse gastric cancer. Endoscopy is regarded as insufficient for early detection due to the infiltrative phenotype of diffuse-type cancers. Microscopic foci of invasive signet ring cells are pathognomonic of CDH1 and precede development of diffuse gastric cancer. We aimed to assess the safety and effectiveness of endoscopy...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36990610
DOI: 10.1016/S1470-2045(23)00057-8
PMCID: PMC10084814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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