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Endoscopic Predictors of Early Cancer Burden Allow Optimization of Management Decisions in Hereditary Diffuse Gastric Cancer

2025-10-15

Abstract excerpt

<h4>Introduction</h4> Hereditary diffuse gastric cancer (HDGC) associated with CDH1 germline pathogenic variants (GPV), carries a high lifetime risk of signet ring cell carcinoma (SRCC). Currently, there is uncertainty regarding to whom and when to recommend prophylactic total gastrectomy (PTG). We hypothesise a small number of early SRCC lesions correlates with low risk of progression to clinical gastric cancer...

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Literature Corpus work
aa140f77-8aff-53a6-9337-db27450c43a8
DOI
10.1101/2025.10.13.25337824
Open publication

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Endoscopic Predictors of Early Cancer Burden Allow Optimization of Management Decisions in Hereditary Diffuse Gastric CancerDOI 10.1101/2025.10.13.25337824
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