Article
Laparoscopic Prophylactic Total Gastrectomy for Hereditary Diffuse Gastric Cancer in CDH1 Mutation Carriers.
Journal of laparoendoscopic & advanced surgical techniques. Part A - 1 Jul 2021
Ithurralde-Argerich Javier, Rosner Laura, Rizzolo Mariana, Faerberg Alejandro, Puma Rolando, Ferro Diego, Duque Camilo, Kujaruk Mirta, Cuenca-Abente Federico
Abstract excerpt
Background: Patients with hereditary diffuse gastric cancer (HDGC) and germline mutations in the E-cadherin gene, CDH1, have a very high cumulative lifetime risk of developing diffuse gastric cancer. In these patients, it is formally recommended to perform a prophylactic total gastrectomy (PTG). Materials and Methods: We analyzed the course of patients with HDGC who have undergone PTG in our institution. Pedigree...
Topics
- Adolescent
- Adult
- Antigens, CD
- Cadherins
- Female
- Gastrectomy
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Laparoscopy