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Article

Laparoscopic Prophylactic Total Gastrectomy for Hereditary Diffuse Gastric Cancer in CDH1 Mutation Carriers.

Journal of laparoendoscopic & advanced surgical techniques. Part A - 1 Jul 2021

Ithurralde-Argerich Javier, Rosner Laura, Rizzolo Mariana, Faerberg Alejandro, Puma Rolando, Ferro Diego, Duque Camilo, Kujaruk Mirta, Cuenca-Abente Federico

Abstract excerpt

Background: Patients with hereditary diffuse gastric cancer (HDGC) and germline mutations in the E-cadherin gene, CDH1, have a very high cumulative lifetime risk of developing diffuse gastric cancer. In these patients, it is formally recommended to perform a prophylactic total gastrectomy (PTG). Materials and Methods: We analyzed the course of patients with HDGC who have undergone PTG in our institution. Pedigree...

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Identifiers

PMID: 34097461
DOI: 10.1089/lap.2021.0239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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