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A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases

29 Jul 2019

Abstract excerpt

BACKGROUND: Genomic medicine has paved the way for identifying biomarkers and therapeutically actionable targets for complex diseases, but is complicated by the involvement of thousands of variably expressed genes across multiple cell types. Single-cell RNA-sequencing study (scRNA-seq) allows the characterization of such complex changes in whole organs. METHODS: The study is based on applying network tools to...

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PMID: 31358043
DOI: 10.1186/s13073-019-0657-3

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