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Article

The anaphase-promoting complex: A key mitotic regulator associated with somatic mutations occurring in cancer.

Genes, chromosomes & cancer - 1 Mar 2020

Melloy Patricia G

Abstract excerpt

The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that helps control chromosome separation and exit from mitosis in many different kinds of organisms, including yeast, flies, worms, and humans. This review represents a new perspective on the connection between APC/C subunit mutations and cancer. The complex nature of APC/C and limited mutation analysis of its subunits has made it...

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Identifiers

PMID: 31652364
DOI: 10.1002/gcc.22820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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