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Novel Mutations in CDC20 Are Associated with Female Infertility Due to Oocyte Maturation Abnormality and Early Embryonic Arrest.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Jul 2021

Huang Lingli, Wang Fengsong, Kong Shuai, Wang Yu, Song Gaojie, Lu Fangting, Ji Jingjuan, Luo Lihua, Tong Xianhong

Abstract excerpt

The cell division cycle 20 (CDC20) protein is a co-activator of anaphase-promoting complex/cyclosome (APC/C), required for mitotic exit and also meiotic exit, containing seven WD40 repeats in the C-terminus responsible for protein-protein interactions. Recently, a previous study has shown that biallelic mutations in CDC20 are causative for female infertility with abnormalities in oocyte maturation and embryonic...

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Identifiers

PMID: 33683667
DOI: 10.1007/s43032-021-00524-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Novel Mutations in CDC20 Are Associated with Female Infertility Due to Oocyte Maturation Abnormality and Early Embryonic Arrest.PMID 33683667Read ↗

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