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Article

BUB1B monoallelic germline variants contribute to prostate cancer predisposition by triggering chromosomal instability.

Journal of biomedical science - 16 Jul 2024

Silva Maria P, Ferreira Luísa T, Brás Natércia F, Torres Lurdes, Brandão Andreia, Pinheiro Manuela, Cardoso Marta, Resende Adriana, Vieira Joana, Palmeira Carlos, Martins Gabriela, Silva Miguel, Pinto Carla, Peixoto Ana, Silva João, Henrique Rui, Maia Sofia, Maiato Helder, Teixeira Manuel R, Paulo Paula

Abstract excerpt

BACKGROUND: Prostate cancer (PrCa) is the most frequently diagnosed cancer in men. Variants in known moderate- to high-penetrance genes explain less than 5% of the cases arising at early-onset (< 56 years) and/or with familial aggregation of the disease. Considering that BubR1 is an essential component of the mitotic spindle assembly checkpoint, we hypothesized that monoallelic BUB1B variants could be sufficient...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39014450
DOI: 10.1186/s12929-024-01056-z
PMCID: PMC11251299

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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