Article
Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation.
Aging cell - 1 Nov 2020
Fujita Harumi, Sasaki Takashi, Miyamoto Tatsuo, Akutsu Silvia Natsuko, Sato Showbu, Mori Takehiko, Nakabayashi Kazuhiko, Hata Kenichiro, Suzuki Hisato, Kosaki Kenjiro, Matsuura Shinya, Matsubara Yoichi, Amagai Masayuki, Kubo Akiharu
Abstract excerpt
Damage to the genome can accelerate aging. The percentage of aneuploid cells, that is, cells with an abnormal number of chromosomes, increases during aging; however, it is not clear whether increased aneuploidy accelerates aging. Here, we report an individual showing premature aging phenotypes of various organs including early hair loss, atrophic skin, and loss of hematopoietic stem cells; instability of...
Topics
- Aging, Premature
- Cdc20 Proteins
- Female
- Humans
- Middle Aged
- Mutation