Article

Role of coiled-coil registry shifts in activation of human Bicaudal D2 for dynein recruitment upon cargo-binding

2019-05-15

Abstract excerpt

<h4>SUMMARY</h4> Dynein adaptors such as Bicaudal D2 (BicD2) recognize cargo for dynein-dependent transport. BicD2-dependent transport pathways are important for brain and muscle development. Cargo-bound adaptors are required to activate dynein for processive transport, but the mechanism of action is elusive. Here, we report the structure of the cargo-binding domain of human BicD2 that forms a dimeric coiled-coil...

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Literature Corpus work: dbe8fc99-e2c9-5c86-9eab-02483765bfb0
DOI: 10.1101/638536

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