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Article

Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dynein.

Genes & development - 1 Jun 2013

Liu Yang, Salter Hannah K, Holding Andrew N, Johnson Christopher M, Stephens Elaine, Lukavsky Peter J, Walshaw John, Bullock Simon L

Abstract excerpt

Cytoplasmic dynein is the major minus end-directed microtubule motor in eukaryotes. However, there is little structural insight into how different cargos are recognized and linked to the motor complex. Here we describe the 2.2 Å resolution crystal structure of a cargo-binding region of the dynein adaptor Bicaudal-D (BicD), which reveals a parallel coiled-coil homodimer. We identify a shared binding site for two...

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Identifiers

PMID: 23723415
DOI: 10.1101/gad.212381.112
PMCID: PMC3690397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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