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Cytoplasmic dynein-2 at a glance

15 Mar 2020

Abstract excerpt

ABSTRACT Cytoplasmic dynein-2 is a motor protein complex that drives the movement of cargoes along microtubules within cilia, facilitating the assembly of these organelles on the surface of nearly all mammalian cells. Dynein-2 is crucial for ciliary function, as evidenced by deleterious mutations in patients with skeletal abnormalities. Long-standing questions include how the dynein-2 complex is assembled,...

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PMID: 32229580
DOI: 10.1242/jcs.240614

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