Article

Cargo recognition of Nesprin-2 by the dynein adapter Bicaudal D2 for a nuclear positioning pathway that is important for brain development

2025-05-23

Abstract excerpt

<h4>ABSTRACT</h4> Nesprin-2 and its paralog Nesprin-1 are subunits of LINC complexes that are essential for brain development. To position the nucleus for neuronal migration, Nesprin-2 interacts with the motors kinesin-1 and dynein, which are recruited by the adapter Bicaudal D2 (BicD2), but the molecular details of these interactions are elusive. Here, structural models of minimal Nesprin-2/BicD2 complexes with...

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Literature Corpus work: a9a13282-9c84-55b4-8c74-7d6572a709d2
DOI: 10.1101/2025.05.18.654709

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