Article
Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 2011
Zhu Jiang, Yu Yong, Ulbrich Maximilian H, Li Ming-hui, Isacoff Ehud Y, Honig Barry, Yang Jian
Abstract excerpt
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in TRPP2 and PKD1, which form an ion channel/receptor complex containing three TRPP2 and one PKD1. A TRPP2 C-terminal coiled-coil trimer, critical for the assembly of this complex, associates with a single PKD1 C-terminal coiled-coil. Many ADPKD pathogenic mutations result in the abolishment of the TRPP2/PKD1 coiled-coil complex. To gain...
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