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Article

Molecular mechanism for recognition of the cargo adapter Rab6GTP by the dynein adapter BicD2.

Life science alliance - 1 Jul 2024

Zhao Xiaoxin, Quintremil Sebastian, Rodriguez Castro Estrella D, Cui Heying, Moraga David, Wang Tingyao, Vallee Richard B, Solmaz Sozanne R

Abstract excerpt

Rab6 is a key modulator of protein secretion. The dynein adapter Bicaudal D2 (BicD2) recruits the motors cytoplasmic dynein and kinesin-1 to Rab6GTP-positive vesicles for transport; however, it is unknown how BicD2 recognizes Rab6. Here, we establish a structural model for recognition of Rab6GTP by BicD2, using structure prediction and mutagenesis. The binding site of BicD2 spans two regions of Rab6 that undergo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38719748
DOI: 10.26508/lsa.202302430
PMCID: PMC11077774

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