Article

Dynamin-2 Phosphorylation as A Critical Regulatory Target of Bin1 and GSK3α for Endocytosis in Muscle

2021-10-11

Abstract excerpt

<h4>ABSTRACT</h4> Tight regulation of endocytosis ensures accurate control of cellular signaling and membrane dynamics, which are crucial for tissue morphogenesis and functions. Mutations of Bin1 and dynamin-2 (Dyn2), proteins that generate membrane curvature and sever endocytic invaginations, respectively, cause progressive hereditary myopathy. Here, we show that Bin1 inhibits Dyn2 via direct interaction of its...

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Literature Corpus work: ff4dae29-1dd9-5320-aab1-98e253554d7a
DOI: 10.1101/2021.10.11.463889

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