Article

IL-10- and TGF-β-driven BCL6 expression suppresses antiviral defenses and renders lymph node T follicular helper cells permissive to HIV infection

2026-03-13

Abstract excerpt

<title>Abstract</title> Lymph nodes (LNs) constitute a key anatomical sanctuary for HIV. Follicular helper T (Tfh) cells expand early upon infection and represent a principal cellular target for initial viral seeding. Here, we identified the transcription factor BCL6, a Tfh-lineage defining marker, as central in favoring the infection of Tfh cells in LNs during the untreated phase in humans, and for the persis...

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Literature Corpus work: dbe1152b-1a8e-52bf-b17b-614f9d9db492
DOI: 10.21203/rs.3.rs-8919968/v1

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