Article

Interleukin-6 restricts pre-thymic T cell lineage commitment of progenitors driving loss of SIV control

2026-03-13

Abstract excerpt

<title>Abstract</title> <p>Effective T cell reconstitution in people living with HIV is central to durable immune control and cure strategies. Sustained thymic output underpins T cell recovery and requires continuous seeding by T cell-committed progenitors originating in the bone marrow (BM). Using the SIV/rhesus macaque model, we identified a lymphoid thymus-seeding progenitor (TSP; CD4⁻CD8⁻CD34⁺CD38⁻CD7⁺) in BM...

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Literature Corpus work: aba436e3-1db2-5848-97ba-e889cc0b3817
DOI: 10.21203/rs.3.rs-8824573/v1

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