Article
HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells.
Cell reports - 12 Apr 2022
Reuschl Ann-Kathrin, Mesner Dejan, Shivkumar Maitreyi, Whelan Matthew V X, Pallett Laura J, Guerra-Assunção José Afonso, Madansein Rajhmun, Dullabh Kaylesh J, Sigal Alex, Thornhill John P, Herrera Carolina, Fidler Sarah, Noursadeghi Mahdad, Maini Mala K, Jolly Clare
Abstract excerpt
HIV-1 replicates in CD4+ T cells, leading to AIDS. Determining how HIV-1 shapes its niche to create a permissive environment is central to informing efforts to limit pathogenesis, disturb reservoirs, and achieve a cure. A key roadblock in understanding HIV-T cell interactions is the requirement to activate T cells in vitro to make them permissive to infection. This dramatically alters T cell biology and...
Topics
- Humans
- CD4-Positive T-Lymphocytes
- HIV Infections
- HIV-1
- Memory T Cells
- Phenotype
- Virus Replication
- vpr Gene Products, Human Immunodeficiency Virus