Article

Interleukin-6 restricts pre-thymic T cell lineage commitment of progenitors driving loss of SIV control

2026-02-02

Abstract excerpt

Effective T cell reconstitution in people living with HIV is central to durable immune control and cure strategies. Sustained thymic output underpins T cell recovery and requires continuous seeding by T cell-committed progenitors originating in the bone marrow (BM). Using the SIV/rhesus macaque model, we identified a thymus-seeding progenitor (TSP; CD4⁻CD8⁻CD34⁺CD38⁻CD7⁺) in BM declining rapidly following SIV infe...

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Literature Corpus work: 5143fc5f-1871-5f74-92a3-960cdd78eda6
DOI: 10.64898/2026.01.29.702123

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