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TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs <i>in vivo</i>

2023-09-07

Abstract excerpt

HIV-1 persistence during ART is due to the establishment of long-lived viral reservoirs in resting immune cells. Using an NHP model of barcoded SIVmac239 intravenous infection and therapeutic dosing of the anti-TGFBR1 inhibitor galunisertib (LY2157299), we confirmed the latency reversal properties of in vivo TGF-β blockade, decreased viral reservoirs and stimulated immune responses. Eight SIV-infected macaques on...

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Literature Corpus work
cd7c4baa-515d-5fc6-9812-4377e5e55b7e
DOI
10.1101/2023.09.05.556422
Open publication

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TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs <i>in vivo</i>DOI 10.1101/2023.09.05.556422
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