Article

ApoE4-carrying Human Astrocytes Oversupply Cholesterol into Neurons and Promote Aβ Generation

2020-12-31

Abstract excerpt

<title>Abstract</title> <p>The onset of Alzheimer’s disease (AD) typically occurs later in life. Importantly, however, recent genetic analysis of patients and unaffected individuals revealed multiple genetic variants associated with late-onset AD. One of the strongest genetic risk factors for AD is 𝜀4 allele of <italic>APOE</italic> encoding apolipoprotein (ApoE), which is predominantly expressed in glial cells....

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Literature Corpus work: e7725038-25ba-5c58-86a9-4fa16bd2d0ed
DOI: 10.21203/rs.3.rs-122857/v2

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