Article

Early oligodendrocyte dysfunction signature in Alzheimer’s disease: Insights from DNA methylomics and transcriptomics

2025-08-28

Abstract excerpt

<h4>ABSTRACT</h4> Much research into the aetiology of Alzheimer’s disease (AD) has focused on neuronal cell types, while studies on the contribution of glial cells, particularly oligodendrocytes (OLGs), are only starting to emerge. Altered brain DNA methylation, an epigenetic modification that provides the interplay between genetics and environmental cues to tightly regulate gene expression, is well documented in...

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Literature Corpus work: f9c65ae5-6e38-5188-93cd-d8ac25d07922
DOI: 10.1101/2025.08.28.672821

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