Article

Epigenomic subtypes of late-onset Alzheimer’s disease reveal distinct microglial signatures

2025-08-04

Abstract excerpt

<title>Abstract</title> <p>Growing evidence suggests that clinical, pathological, and genetic heterogeneity in late onset Alzheimer’s disease (LOAD) contributes to variable therapeutic outcomes, potentially explaining many trial failures. Advances in molecular subtyping through proteomic and transcriptomic profiling reveal distinct patient subgroups, highlighting disease complexity beyond amyloid-beta plaques and...

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Literature Corpus work: ad0a5b31-3fff-50a4-aff0-ac1fe80899b8
DOI: 10.21203/rs.3.rs-7232080/v1

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