Article

The Aging Epigenome: Integrative Analyses Reveal Functional Overlap with Alzheimer’s Disease

2025-06-09

Abstract excerpt

<h4>ABSTRACT</h4> Aging is the strongest risk factor for Alzheimer’s disease (AD), yet the role of age-associated DNA methylation (DNAm) changes in blood and their relevance to AD remains poorly understood. In this study, we performed a meta-analysis of blood DNAm samples from 475 dementia-free subjects aged over 65 years across two independent cohorts, the Framingham Heart Study (FHS) at Exam 9 and the Alzheimer’...

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Literature Corpus work: 4f1d6f0e-de41-5348-abed-e0e1106d077e
DOI: 10.1101/2025.06.08.25329218

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