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Epigenetic Rewiring Connects Aging to Alzheimer’s Pathology in the Human Prefrontal Cortex

2025-08-29

Abstract excerpt

<title>Abstract</title> <p>The epigenetic mechanisms that connect aging to neurodegeneration remain incompletely understood, particularly in non-European populations. To address this gap, we constructed a comprehensive DNA methylation atlas of the human prefrontal cortex (PFC) from 1,057 postmortem brain samples (ages 1-106) as part of the China Brain Multi-Omics Atlas Project (CBMAP). This represents the largest...

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Literature Corpus work
b2e969cf-7e7d-57d6-a554-20040bae94d9
DOI
10.21203/rs.3.rs-7381745/v1
Open publication

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Epigenetic Rewiring Connects Aging to Alzheimer’s Pathology in the Human Prefrontal CortexDOI 10.21203/rs.3.rs-7381745/v1
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