Article

A conformational switch driven by phosphorylation regulates Ykt6 activity in macroautophagy

2020-03-15

Abstract excerpt

<h4>ABSTRACT</h4> Membrane fusion, an essential process in all eukaryotes, is driven by SNARE proteins. Ykt6 is an essential SNARE that plays critical roles throughout the secretory, endocytic, and autophagy pathways. Ykt6 activity is thought to be regulated by a conformational change from a closed cytosolic form to an open membrane-bound form, yet the mechanism that regulates this transition is unknown. Through...

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Literature Corpus work: db7efb66-8e7f-54a5-93a3-8038e0dd1e6a
DOI: 10.1101/2020.03.15.992727

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