Article

Mechanism of phosphoinositide regulation of lysosomal pH via inhibition of CLC-7

2025-10-02

Abstract excerpt

<h4> Abstract </h4> Lysosomes process cellular waste and coordinate responses to metabolic challenge. Central to lysosomal homeostasis are phosphoinositide lipids, key signaling molecules which establish organelle identity, regulate membrane dynamics and are tightly linked to the pathophysiology and therapy of lysosomal storage disorders, neurodegeneration, and cancer. Phosphatidylinositol 3,5- bisphosphate (PI(...

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Literature Corpus work: ecd2bee9-e5e5-5233-ac45-801cfc4e6b92
DOI: 10.1101/2025.10.01.679551

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