Article

Structural and Dynamic Effects of PTEN C-terminal Tail Phosphorylation

2022-04-16

Abstract excerpt

<h4>ABSTRACT</h4> The phosphatase and tensin homolog deleted on chromosome ten ( PTEN ) tumor suppressor gene encodes a tightly regulated dual-specificity phosphatase that serves as the master regulator of PI3K/AKT/mTOR signaling. The carboxy-terminal tail (CTT) is key to regulation and harbors multiple phosphorylation sites (Ser/Thr residues 380-385). CTT phosphorylation suppresses the phosphatase activity by i...

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Literature Corpus work: ebc1af57-2045-5faf-a9c4-8d38fe5055f3
DOI: 10.1101/2022.04.16.488508

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