Article

Vesicle docking and fusion pore modulation by the neuronal calcium sensor Synaptotagmin-1

2024-09-12

Abstract excerpt

<h4>ABSTRACT</h4> Synaptotagmin-1 (Syt1) is a major calcium sensor for rapid neurotransmitter release in neurons and hormone release in many neuroendocrine cells. It possesses two tandem cytosolic C2 domains that bind calcium, negatively charged phospholipids, and the neuronal SNARE complex. Calcium binding to Syt1 triggers exocytosis, but how this occurs is not well understood. Syt1 has additional roles in docki...

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Literature Corpus work: 2bac7668-a904-57b3-a5d6-f6ea0339487b
DOI: 10.1101/2024.09.12.612660

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