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Article

A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization.

The Journal of biological chemistry - 28 May 2010

Iwaya Naoko, Kuwahara Yohta, Fujiwara Yoshie, Goda Natsuko, Tenno Takeshi, Akiyama Kohei, Mase Shogo, Tochio Hidehito, Ikegami Takahisa, Shirakawa Masahiro, Hiroaki Hidekazu

Abstract excerpt

Katanin p60 (kp60), a microtubule-severing enzyme, plays a key role in cytoskeletal reorganization during various cellular events in an ATP-dependent manner. We show that a single domain isolated from the N terminus of mouse katanin p60 (kp60-NTD) binds to tubulin. The solution structure of kp60-NTD was determined by NMR. Although their sequence similarities were as low as 20%, the structure of kp60-NTD revealed...

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Share to Adenosine Triphosphatases
Share to ATPases Associated with Diverse Cellular Activities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Endosomal Sorting Complexes Required for Transport

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Identifiers

PMID: 20339000
DOI: 10.1074/jbc.M110.108365
PMCID: PMC2878028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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