Article
A lipid switch unlocks Parkinson's disease-associated ATP13A2.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 2015
Holemans Tine, Sørensen Danny Mollerup, van Veen Sarah, Martin Shaun, Hermans Diane, Kemmer Gerdi Christine, Van den Haute Chris, Baekelandt Veerle, Günther Pomorski Thomas, Agostinis Patrizia, Wuytack Frank, Palmgren Michael, Eggermont Jan, Vangheluwe Peter
Abstract excerpt
ATP13A2 is a lysosomal P-type transport ATPase that has been implicated in Kufor-Rakeb syndrome and Parkinson's disease (PD), providing protection against α-synuclein, Mn(2+), and Zn(2+) toxicity in various model systems. So far, the molecular function and regulation of ATP13A2 remains undetermined. Here, we demonstrate that ATP13A2 contains a unique N-terminal hydrophobic extension that lies on the cytosolic...
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