Article
Intramolecular protein-protein and protein-lipid interactions control the conformation and subcellular targeting of neuronal Ykt6.
Journal of cell science - 1 Sept 2004
Hasegawa Haruki, Yang Zhifen, Oltedal Leif, Davanger Svend, Hay Jesse C
Abstract excerpt
Although the membrane-trafficking functions of most SNAREs are conserved from yeast to humans, some mammalian SNAREs have evolved specialized functions unique to multicellular life. The mammalian homolog of the prenylated yeast SNARE Ykt6p might be one such example, because rat Ykt6 is highly expressed only in brain neurons. Furthermore, neuronal Ykt6 displayed a remarkably specialized, punctate localization that...
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