Article

N-terminal cardiac myosin-binding protein C interactions with myosin and actin filaments using time-resolved FRET

2022-09-09

Abstract excerpt

Myosin binding protein-C (cMyBP-C) is a sarcomeric protein responsible for normal contraction and relaxation of the heart. We have used time-resolved fluorescence resonance energy transfer (TR-FRET) to resolve the interactions of cardiac myosin and F-actin with cMyBP-C, focusing on the N-terminal region. The results imply roles of these bound protein complexes in myocardial contraction, with particular relevance t...

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Literature Corpus work: 285bb5d4-ac9a-5401-89a1-a06b4866c24e
DOI: 10.1101/2022.09.07.507024

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