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Article

Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy.

eLife - 17 Aug 2026

Arecchi Giulia, Dente Marica, Ma Weikang, Scellini Beatrice, Piroddi Nicoletta, Scardigli Marina, Yu Jingyuan, Zhao Jing, Cicchi Riccardo, Kinegawa Ryo, Muellenbroich Caroline, Sera Francesco, Poggesi Corrado, Ferrantini Cecilia, Irving Thomas C, Regnier Michael, Sacconi Leonardo, Tesi Chiara

Abstract excerpt

This study explores the use of polarized second-harmonic generation (pSHG) to investigate myosin conformation in the relaxed state, differentiating between the actin-available, disordered (ON) state and the energy-conserving, ordered (OFF) state. By shifting the ON/OFF equilibrium using both physical and chemical manipulations, we demonstrate the sensitivity of pSHG in quantifying the ON/OFF ratio in skeletal and...

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Identifiers

PMID: 42606952
DOI: 10.7554/eLife.107730
PMCID: PMC13480991

Genes

MYH7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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