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Article

The Axial Alignment of Titin on the Muscle Thick Filament Supports Its Role as a Molecular Ruler.

Journal of molecular biology - 7 Aug 2020

Bennett Pauline, Rees Martin, Gautel Mathias

Abstract excerpt

The giant protein titin is expressed in vertebrate striated muscle where it spans half a sarcomere from the Z-disc to the M-band and is essential for muscle organisation, activity and health. The C-terminal portion of titin is closely associated with the thick, myosin-containing filament and exhibits a complex pattern of immunoglobulin and fibronectin domains. This pattern reflects features of the filament...

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Identifiers

PMID: 32619437
DOI: 10.1016/j.jmb.2020.06.025
PMCID: PMC7427331

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Axial Alignment of Titin on the Muscle Thick Filament Supports Its Role as a Molecular Ruler.PMID 32619437Read ↗

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