Article

Cryo-EM structure of the folded-back state of human β-cardiac myosin*

2023-04-18

Abstract excerpt

<h4>Summary</h4> During normal levels of exertion, many cardiac muscle myosin heads are sequestered in an off-state even during systolic contraction to save energy and for precise regulation. They can be converted to an on-state when exertion is increased. Hypercontractility caused by hypertrophic cardiomyopathy (HCM) myosin mutations is often the result of shifting the equilibrium toward more heads in the on-sta...

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Literature Corpus work: fe226344-dd43-5d77-a28c-884e7b7de6f2
DOI: 10.1101/2023.04.15.536999

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