Article
Dynamics of the β-cardiac myosin auto-inhibited state explain cardiomyopathy pathogenesis.
Nature communications - 4 Jun 2026
Auguin Daniel, Lannes Laurie, Kikuti Carlos, Ayoub Nour, Juillé Marie, Réty Stéphane, Nandwani Neha, Pathak Divya, Ruppel Kathleen M, Spudich James A, Robert-Paganin Julien, Houdusse Anne
Abstract excerpt
Cardiac contractility requires precise regulation. A recently discovered form of regulation of cardiac contractility involves a β-cardiac myosin off-state, the Interacting-Heads Motif (CarIHM). Despite its central role in cardiac physiology and disease, CarIHM structural dynamics remain poorly understood. Here, we integrate near-atomic resolution cryo-EM with all-atom molecular dynamics to characterize CarIHM in...
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