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Article

Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments.

Journal of molecular biology - 22 Sept 2000

Lehman W, Hatch V, Korman V, Rosol M, Thomas L, Maytum R, Geeves M A, Van Eyk J E, Tobacman L S, Craig R

Abstract excerpt

Tropomyosin is present in virtually all eucaryotic cells, where it functions to modulate actin-myosin interaction and to stabilize actin filament structure. In striated muscle, tropomyosin regulates contractility by sterically blocking myosin-binding sites on actin in the relaxed state. On activation, tropomyosin moves away from these sites in two steps, one induced by Ca(2+) binding to troponin and a second by...

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Source

Identifiers

PMID: 10986121
DOI: 10.1006/jmbi.2000.4080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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