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Article

Regulation of actin-myosin interaction by conserved periodic sites of tropomyosin.

Proceedings of the National Academy of Sciences of the United States of America - 6 Nov 2012

Barua Bipasha, Winkelmann Donald A, White Howard D, Hitchcock-DeGregori Sarah E

Abstract excerpt

Cooperative activation of actin-myosin interaction by tropomyosin (Tm) is central to regulation of contraction in muscle cells and cellular and intracellular movements in nonmuscle cells. The steric blocking model of muscle regulation proposed 40 y ago has been substantiated at both the kinetic and structural levels. Even with atomic resolution structures of the major players, how Tm binds and is designed for...

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Identifiers

PMID: 23091026
DOI: 10.1073/pnas.1212754109
PMCID: PMC3494946

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of actin-myosin interaction by conserved periodic sites of tropomyosin.PMID 23091026Read ↗

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