Article

Electron microscopy reveals toroidal shape of master neuronal cell differentiator REST – RE1-Silencing Transcription factor

2022-10-06

Abstract excerpt

The RE1-Silencing Transcription factor (REST) is essential for neuronal differentiation. Here, we report the first 18.5-angstrom electron microscopy structure of human REST. The refined electron map suggests that REST forms a torus that can accommodate DNA double-helix in the central hole. Additionally, we quantitatively described REST binding to the canonical DNA sequence of the neuron-restrictive silencer elemen...

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Literature Corpus work: db05e404-942a-582d-83a6-ac2bac2372cc
DOI: 10.1101/2022.10.06.511111

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