Article

Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by minor groove anchor competition

2023-06-14

Abstract excerpt

Gene expression during natural and induced reprogramming is controlled by pioneer transcription factors, which bind nucleosomal DNA and initiate gene expression from closed chromatin. How pioneer factors perform this function is poorly understood. Nr5a2 is a pioneer factor that is critical for zygotic genome activation (ZGA) in totipotent embryos, pluripotency in embryonic stem cells and metabolic regulation in ad...

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Literature Corpus work: a3c9503e-b5b4-547f-aa62-c0078039470f
DOI: 10.1101/2023.06.14.544949

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