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Article

Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes.

Nature neuroscience - 1 Oct 1999

Huang Y, Myers S J, Dingledine R

Abstract excerpt

Many genes whose expression is restricted to neurons in the brain contain a silencer element (RE1/NRSE) that limits transcription in nonneuronal cells by binding the transcription factor REST (also named NRSF or XBR). Although two independent domains of REST are known to confer repression, the mechanisms of transcriptional repression by REST remain obscure. We provide multiple lines of evidence that the...

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Share to Acetylation
Share to Enzyme Inhibitors
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hydroxamic Acids

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Source

Identifiers

PMID: 10491605
DOI: 10.1038/13165

Genes

REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes.PMID 10491605Read ↗

NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis.Semantic proximity Read ↗

The Importance of REST for Development and Function of Beta CellsSemantic proximity Read ↗

<i>REST</i> and <i>RCOR</i> genes display distinct expression profiles in neurons and astrocytes using 2D and 3D human pluripotent stem cell modelsSemantic proximity Read ↗

Absence of binding activity of neuron-restrictive silencer factor is necessary, but not sufficient for transcription of NMDA receptor subunit type 1 in neuronal cells.Semantic proximity Read ↗

Repressor element-1 silencing transcription/neuron-restrictive silencer factor is required for neural sodium channel expression during development of Xenopus.Semantic proximity Read ↗

Suppression of Sin3A activity promotes differentiation of pluripotent cells into functional neurons.Semantic proximity Read ↗

NRSF–mediated repression of neuronal genes in developing brain persists in the absence of NRSF-Sin3 interactionSemantic proximity Read ↗

Repressor Element-1 Binding Transcription Factor (REST) as a Possible Epigenetic Regulator of Neurodegeneration and MicroRNA-Based Therapeutic StrategiesSemantic proximity Read ↗

Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines.Semantic proximity Read ↗

SIRT6-dependent functional switch via K494 modifications of RE-1 Silencing Transcription factorSemantic proximity Read ↗

Reciprocal actions of REST and a microRNA promote neuronal identity.Semantic proximity Read ↗

Biological activity of RE-1 silencing transcription factor (REST) towards distinct transcriptional activators.Semantic proximity Read ↗

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