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Article

A core–BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes

28 May 2002

Abstract excerpt

BRAF35, a structural DNA-binding protein, initially was identified as a component of a large BRCA2-containing complex. Biochemical analysis revealed the presence of a smaller core-BRAF35 complex devoid of BRCA2. Here we report the isolation of a six-subunit core-BRAF35 complex with the capacity to deacetylate histones, termed the BRAF-histone deacetylase complex (BHC), from human cells. BHC contains polypeptides...

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PMID: 12032298
DOI: 10.1073/pnas.112008599

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