Article

Dysregulation of NRSF/REST via EHMT1 is associated with psychiatric disorders

2021-04-26

Abstract excerpt

<h4>Summary</h4> Genetic evidence indicates disrupted epigenetic regulation as a major risk factor for psychiatric disorders, but the molecular mechanisms that drive this association are undetermined. EHMT1 is an epigenetic repressor that is causal for Kleefstra Syndrome (KS), a neurodevelopmental disorder (NDD) leading to ID, and is associated with schizophrenia. Here, we show that reduced EHMT1 activity decreas...

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Literature Corpus work: 0265aa3f-7618-5b3b-92e1-6b92569a1283
DOI: 10.1101/2021.04.26.441439

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