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Article

REST/NRSF deficiency impairs autophagy and leads to cellular senescence in neurons

14 Sept 2021

Abstract excerpt

During aging, brain performances decline. Cellular senescence is one of the aging drivers and a key feature of a variety of human age-related disorders. The transcriptional repressor RE1-silencing transcription factor (REST) has been associated with aging and higher risk of neurodegenerative disorders. However, how REST contributes to the senescence program and functional impairment remains largely unknown. Here,...

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Share to Autophagy in Disease and Therapy
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PMID: 34520100
DOI: 10.1111/acel.13471

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