Article

SIRT6-dependent functional switch via K494 modifications of RE-1 Silencing Transcription factor

2024-07-17

Abstract excerpt

<title>Abstract</title> <p><italic>RE-1 Silencing Transcription factor (REST)</italic> <italic>is a key repressor of neural genes. REST is upregulated under stress signals, aging and neurodegenerative diseases, but although it is upregulated, it loses its function in Alzheimer's Disease. However, why it becomes inactive remains unclear. Here, we show that the NAD-dependent deacetylase SIRT6 regulates REST express...

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Literature Corpus work: d7ba3bd7-c6c2-5946-8a24-4735f338a5dc
DOI: 10.21203/rs.3.rs-4371623/v1

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