Article

Genome-wide assessment of REST binding profiles reveals distinctions between human and mouse hippocampus

2020-07-07

Abstract excerpt

<h4>Background</h4> The transcriptional repressor, RE1 Silencing Transcription Factor (REST), recognized historically as a master regulator of neuronal gene expression during mouse development, has recently been ascribed roles in human aging and neurodegenerative disorders. However, REST’s role in healthy adult human brain, and how faithfully mouse models reproduce REST function in human brain, is not known. <h4>...

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Literature Corpus work: 7784a5a2-2816-5b2b-98c9-d7519edaa44b
DOI: 10.1101/2020.07.07.192229

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