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A Computational and Biochemical Study of -1 Ribosomal Frameshifting in Human mRNAs

2021-04-24

Abstract excerpt

−1 programmed ribosomal frameshifting (−1 PRF) is a translational recoding mechanism used by many viral and cellular mRNAs. −1 PRF occurs at a heptanucleotide slippery sequence and is stimulated by a downstream RNA structure, most often in the form of a pseudoknot. The utilization of −1 PRF to produce proteins encoded by the −1 reading frame is wide-spread in RNA viruses, but relatively rare in cellular mRNAs. In...

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Literature Corpus work
38ba3b10-dae4-51ef-a196-22284e162ebc
DOI
10.1101/2021.04.23.441185
Open publication

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A Computational and Biochemical Study of -1 Ribosomal Frameshifting in Human mRNAsDOI 10.1101/2021.04.23.441185
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