Article

A Statistical Detector for Ribosomal Frameshifts and Dual Encodings based on Ribosome Profiling

2022-06-06

Abstract excerpt

<h4>ABSTRACT</h4> During protein synthesis, the ribosome shifts along the messenger RNA (mRNA) by exactly three nucleotides for each amino acid added to the protein being translated. However, in special cases, the sequence of the mRNA somehow induces the ribosome to shift forward by either two or four nucleotides. This shifts the “reading frame” in which the mRNA is translated, and gives rise to an otherwise unex...

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Literature Corpus work: e0f154e8-9620-5982-aede-632f162efe96
DOI: 10.1101/2022.06.06.495024

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